您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Coleon-U-quinone
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Coleon-U-quinone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Coleon-U-quinone图片
CAS NO:65714-83-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Coleon-U-quinone 是一种有效的P-gp抑制剂。Coleon-U-quinone 能抑制癌细胞活力,能提高多药耐药肿瘤细胞对 Doxorubicin (HY-15142A) 的敏感性。
生物活性

Coleon-U-quinone is a potentP-gpinhibitor. Coleon-U-quinone can inhibitcancercells viability and sensitize multidrug resistancecancercells toDoxorubicin(HY-15142A)[1].

IC50& Target

P-glycoprotein[1]

体外研究
(In Vitro)

Coleon-U-quinone (0-50 μM; 72 h) has inhibitory activity against NCI-H460, NCI-H460/R and MRC-5[1].
Coleon-U-quinone (1-5 μM; 72 h) sensitize NCI-H460/R cells toDoxorubicin(HY-15142A)[1].

Cell Viability Assay[1]

Cell Line:NCI-H460, NCI-H460/R and MRC-5
Concentration:0-50 μM
Incubation Time:72 h
Result:Exhibited inhibitory activity against NCI-H460, NCI-H460/R and MRC-5 with IC50s of 22.96 ± 0.56 μM, 20.37 ± 0.43 μM and 44.13 ± 1.19 μM.

Cell Proliferation Assay[1]

Cell Line:NCI-H460/R
Concentration:1, 2 and 5 μM
Incubation Time:72 h
Result:Sensitized NCI-H460/R cells toDoxorubicin(HY-15142A) with IC50s of 0.565 μM, 0.482 μM and 0.217 μM at 1 μM, 2 μM and 5 μM, respectively.
分子量

344.40

Formula

C20H24O5

CAS 号

65714-83-2

结构分类
  • Ketones, Aldehydes, Acids
来源
  • Plants
  • Labiatae
  • Plectranthus mutabilisCodd
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.