(S)-Verapamil D7 HCl ((S)-(-)-Verapamil D7 HCl) is a deuterated form of (S)-Verapamil HCl. (S)-Verapamil HCl (S(-)-Verapamil HCl) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil HCl leads to the death of highly potentially resistant tumor cells. References: [1]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22.
[2]. Tannergren C, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309.
纯度:≥98%