Folic acid (Vitamin B9) sodium 是一种来自维生素 B 群的口服活性必需营养素。Folic acid sodium 具有抗抑郁样作用。Folic acid sodium 可降低新生儿神经管缺陷的风险。Folic acid sodium 可用于治疗因叶酸缺乏引起的巨幼红细胞性贫血和大红细胞性贫血。
| 生物活性 | Folic acid (Vitamin B9) sodium is a orally active essential nutrient from the B complex group of vitamins. Folic acid sodium shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid sodium can be used to the treatment of megaloblastic and macrocytic anemias due to folic deficiency[1][2][3][4]. |
| IC50& Target | Microbial Metabolite | Human Endogenous Metabolite |
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体外研究
(In Vitro) | Folic acid sodium plays a critical role in the prevention of chromosome breakage and hypomethylation of DNA[1].
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体内研究
(In Vivo) | Folic acid sodium (10, 50, 100 mg/kg; p.o.) shows an antidepressant-like effect in this
behavioral mouse model[2].
Folic acid sodium (1, 10 nmol/site) shows no psychostimulant effect in mice habituated to the novel environment[2].
Folic acid sodium (1, 5 mg/kg; p.o.) prevents epigenetic modification of hepatic gene expression in the offspring in rats[3].
| Animal Model: | 30-40 g swiss mice[2] | | Dosage: | 10, 50, 100 mg/kg | | Administration: | Oral administration | | Result: | Decreased the immobility time in the forced swimming test (FST) (F324=11.21) and produced a significant effect in the immobility time in the tail suspension test (TST) (F3,20=5.71). |
| Animal Model: | 30-40 g swiss mice[2] | | Dosage: | 1-10 nmol/site | | Administration: | Intracerebroventrical injection | | Result: | Decreased the immobility time of mice in the FST (F3,22=12.31) and TST (F3,22=5.50). |
| Animal Model: | Virgin female Wistar rats[3] | | Dosage: | 1, 5 mg/kg (180 g/kg protein with 1 mg/kg folic acid or 90 g/kg casein with 1, 5 mg/kg folic acid) | | Administration: | Oral administration | | Result: | Prevented epigenetic modification of hepatic gene expression in the offspring. |
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| 结构分类 | - Ketones, Aldehydes, Acids
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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