Tolcapone D7 (Ro 40-7592 D7) is a deuterated form of Tolcapone. Tolcapone is a specific, highly potent and orally bioavailable COMT inhibitor. Tolcapone is also a highly potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis and protect against extracellular toxicity induced by the aggregation of both proteins in PC12 cells. References: [1]. Paterson NE, et al. Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and d-amphetamine, but unaffected by the COMT inhibitor tolcapone. Neurosci Res. 2011 Jan;69(1):41-50. [2]. Di Giovanni S, et al. Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem. 2010 May 14;285(20):14941-54.

纯度：≥98%