Deacylcortivazol (DAC) is a novel and potent glucocorticoid agent that contains a phenyl-pyrazole group fused to the 2-3 position of the conventional steroid core. When incubated with glucocorticoid-resistant mutants derived from the glucocorticoid-sensitive human leukemic cell line CEM-C7, DAC caused significant growth inhibition. The cytotoxicity of DAC at concentrations higher than necessary for glucocorticoid receptor saturation is not mediated by glucocorticoid receptors. Thus, DAC may be a bifunctional compound having both steroid receptor-mediated and receptor-independent cytotoxicity.

纯度：≥98%

CAS：4906-84-7