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Fobrepodacin disodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fobrepodacin disodium图片
CAS NO:1384984-20-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
SPR720 disodium
pVXc-486 disodium
产品介绍
Fobrepodacin (SPR720) disodium 是一种具有口服活性的,有效的 SPR719 (VXc-486; HY-12930) 磷酸盐前药。Fobrepodacin disodium 在体内具有很好的杀菌 (bactericidal) 活性。
生物活性

Fobrepodacin (SPR720) disodium is an orally active and potent phosphate prodrug of SPR719 (VXc-486; HY-12930). Fobrepodacin disodium has potentbactericidalactivities in vivo[1].

体内研究
(In Vivo)

Fobrepodacin disodium (oral gavage; 10, 30, 100 mg/kg; once per day; 5 times per week for 4 weeks) reduces the mycobacterial burden in a model of chronic tuberculosis infection in mice[1].
Fobrepodacin disodium (oral; 100 mg/kg; once per day; 5 days per week, for 8 weeks) improves the bactericidal activities of antimycobacterial drugs[1].

Animal Model:Six-week old female BALB/c and C57BL/6 mice uninfected or M. tuberculosis-infected (Erdman)[1]
Dosage:10, 30, 100 mg/kg
Administration:Oral gavage; once per day; 5 times per week for 4 weeks
Result:Reduced the mycobacterial burden in a model of chronic tuberculosis infection in mice.
Clinical Trial
分子量

552.40

Formula

C21H24FN6Na2O6P

CAS 号

1384984-20-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.