CAS NO: | 55142-85-3 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Ticlopidine (PCR 5332), an antithrombotic prodrug, acts as an allosteric, noncompetitive inhibitor ofCD39with theIC50of 81.7 μM. Ticlopidine blocks severalNTPDaseisoenzymes withIC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively[1]. Ticlopidine is an inhibitor ofCYP2C19human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 withIC50s of 26.0 and 32.3 μM, respectively[2][3]. | ||||||||
IC50& Target | Cytochrome P450[1] | ||||||||
体外研究 (In Vitro) | Ticlopidine exhibits activity against human CD39 with apparent Ki,appvalues of 14 μM[1]. Cell Proliferation Assay[4]
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体内研究 (In Vivo) | Oral administration of Losartan with 10 mg/kg Ticlopidine significantly increases the AUC (by 65.0%), suggesting that Ticlopidine can effectively inhibit the metabolism of losartan in the intestine and/or liver[3].
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Clinical Trial | |||||||||
分子量 | 263.79 | ||||||||
Formula | C14H14ClNS | ||||||||
CAS 号 | 55142-85-3 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |