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Fluphenazine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fluphenazine图片
CAS NO:69-23-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
氟奋乃静
产品介绍
Fluphenazine 是一种有效且具有口服活性的吩噻嗪类多巴胺受体 (dopamine receptor)拮抗剂。Fluphenazine 阻断神经元电压门控的钠离子通道 (sodium channels)。Fluphenazine 主要通过拮抗中边缘、黑质纹状体和下颌结节神经通路的突触后多巴胺-2 受体来发挥作用。Fluphenazine 可拮抗苯甲酸甲酯诱导的小鼠刻板咬伤,抑制小鼠攀爬行为。Fluphenazine 可用于研究精神病以及与糖尿病相关的疼痛性周围神经病变,并有抑制SARS-CoV-2的潜力。
生物活性

Fluphenazine is a potent, orally active phenothiazine-baseddopamine receptorantagonist. Fluphenazine blocks neuronal voltage-gatedsodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibitSARS-CoV-2[1][2][3][4][6].

IC50& Target

Dopamine receptor, Sodium channels, SARS-CoV-2[1][2]

体内研究
(In Vivo)

Fluphenazine (1 mg/kg; IG, treated from day 6 to day 15 of gestation) causes malformations in pregnant mice[5].
Fluphenazine (0.125-1 mg/kg; IP, single dosage) antagonizes Methylphenidate-induced stereotyped gnawing; inhibits significantly climbing behaviour[6].

Animal Model:Mice (injected with 60 mg/kg Methylphenidate)[6]
Dosage:0.125, 0.25, 0.5, and 1 mg/kg
Administration:IP, single dosage
Result:Antagonized Methylphenidate-induced stereotyped gnawing; inhibited significantly climbing behaviour in mice at 0.0625-0.5 mg/kg, and at the dose of 1 mg/kg abolished this effect completely.
Animal Model:Mature female Swiss-Webster mice[5]
Dosage:1 mg/kg
Administration:IG, treated from day 6 to day 15 of gestation
Result:Significantly reduced fetal weight and length, increased the incidence of incomplete ossification of sternebrae and skull bones.
Clinical Trial
分子量

437.52

Formula

C22H26F3N3OS

CAS 号

69-23-8

中文名称

氟奋乃静癸EP杂质B

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.