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Domperidone monomaleate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Domperidone monomaleate图片
CAS NO:83898-65-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
R33812 monomaleate
产品介绍
Domperidone (R33812) monomaleate 是一种具有口服活性和选择性的多巴胺-2 受体 (dopamine-2 receptor) 拮抗剂。Domperidone monomaleate 通过影响胃和小肠的化学感受器触发区和运动功能,起到止吐和促动力剂作用。
生物活性

Domperidone (R33812) monomaleate is an orally active and selectivedopamine-2 receptorantagonist. Domperidone monomaleate acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1].

体外研究
(In Vitro)

Cardiac Na+channels are common targets of therapeutics inducing cardiotoxicity[3].
Domperidone monomaleate (0-1000 μM) displays concentration- and state-dependent inhibitory of Nav1.5 in Human embryonic kidney HEK293 cells[3].
Domperidone monomaleate (0, 10, 100 μM) displays tonic and use-dependent block to Na currents in rat cardiomyocytes with a IC50of 312 μM[3].

体内研究
(In Vivo)

Unlike Metoclopramide, Domperidone monomaleate does not cause any adverse neurological symptoms as it has minimal penetration through the blood-brain barrier[1].
Domperidone monomaleate acts as both an antiemetic and an upper gastrointestinal tract prokinetic agent. It is rapidly absorbed after oral administration, and few side effects have been reported[2].

Clinical Trial
分子量

541.98

Formula

C26H28ClN5O6

CAS 号

83898-65-1

中文名称

马来酸多潘立酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.