Trimethobenzamide (Ro 2-9578 free base) is a blocker of theD₂receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting^[1].

D₂receptor^[1]

Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center^[1].

The oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration^[1].

388.46

C₂₁H₂₈N₂O₅

138-56-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.