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SKF-82958
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SKF-82958图片
CAS NO:80751-65-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
(±)-SKF-82958
Chloro-APB
产品介绍
SKF-82958 ((±)-SKF 82958) 是多巴胺D1受体激动剂 (K0.5=4 nM),对 D1 受体有选择性(K0.5=73 nM)。SKF-82958 诱导大鼠纹状体膜多巴胺 D1 受体依赖性腺苷酸环化酶活性(EC50=491 nM)。
生物活性

SKF-82958 ((±)-SKF 82958) is adopamine D1 receptorfull agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 induces dopamine D1 receptor-dependentadenylate cyclaseactivity in rat striatal membranes (EC50=491 nM)[1].

体内研究
(In Vivo)

SKF-82958 ((±)-SKF 82958) (0.003-0.1 mg/kg; i.p.) results in dose-dependent increases in responding on the SKF-82958 appropriate lever, with full substitution following administration of the SKF-82958 training dose 0.03 mg/kg. Increasing the dose of SKF-82958 also results in a significant reduction in response rate[2].
SKF-82958 (0.5-2.0 mg/kg; i.p) significantly suppresses pilocarpine-induced jaw movements[3].

Animal Model:Male Sprague-Dawley rats[3]
Dosage:0.5-2.0 mg/kg
Administration:I.p
Result:Significantly reduced the number of tremulous jaw movements induced by 4.0 mg/kg pilocarpine.
分子量

329.82

Formula

C19H20ClNO2

CAS 号

80751-65-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.