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Dihydrexidine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dihydrexidine图片
CAS NO:123039-93-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
DAR-0100
产品介绍
Dihydrexidine (DAR-0100) 是一种高效、选择性和全效的 D1 样多巴胺受体(D1/D5)激动剂,对 D1 受体作用的IC50值为 10 nM。Dihydrexidine 具有高效的抗帕金森活性。Dihydrexidine 可以刺激 YAP 磷酸化。
生物活性

Dihydrexidine (DAR-0100) is a high potent, selective and full efficacyD1-likedopamine receptor(D1/D5)agonist with anIC50of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity[1][2][3][4]. Dihydrexidine can stimulateYAPphosphorylation[5].

IC50& Target

IC50: 10 nM (D1 dopamine receptor), D5 dopamine receptor, 660 nM (D1 dopamine receptor)[1]

体外研究
(In Vitro)

Dihydrexidine (DAR-0100) strongly increased YAP phosphorylation in U2OS cells[5].

体内研究
(In Vivo)

Dihydrexidine has poor oral bioavailability and a relatively short half-life of 1 to 2 h[3].
Dihydrexidine (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo[4].

Animal Model:Adult male Sprague–Dawley rats (275-300 g)[4]
Dosage:Adult male Sprague–Dawley rats (275-300 g)[4]
Administration:Intraperitoneal injection
Result:Produces prominent dopamine D1 receptor agonist effects in vivo
Clinical Trial
分子量

267.32

Formula

C17H17NO2

CAS 号

123039-93-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.