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Cotadutide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1686108-82-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
MEDI0382
产品介绍
Cotadutide (MEDI0382) 是一种有效的胰高血糖素样肽-1 (GLP-1) 和胰高血糖素受体 (GCGR) 双重激动剂,EC50值分别为 6.9 pM 和 10.2 pM。Cotadutide 可促进减肥,控制血糖,以及减轻纤维化。Cotadutide 可用于肥胖和 2 型糖尿病 (T2D) 的研究。
生物活性

Cotadutide (MEDI0382) is a potent dual agonist ofglucagon-like peptide-1 (GLP-1)andGCGRwithEC50values of 6.9 pM and 10.2 pM, respectively. Cotadutide exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide can be used in the research of obesity and type 2 diabetes (T2D)[1][2][3].

IC50& Target

EC50: 6.9 pM (GLP-1); 10.2 pM (GCGR)[1]

体外研究
(In Vitro)

Cotadutide stimulates a concentration-dependent increase in cAMP accumulation in rat (INS-1 832/3) and human (EndoC-βH1) β-cell lines (EC50: 226 pM and 1051 pM, respectively ), as well as rat, mouse and human hepatocytes (EC50: 462 pM, 840 pM, 1447 pM, respectively)[1].
Cotadutide (100 pM-1 μM) potentiates glucose-stimulated insulin secretion in the rat (INS-1 832/3) pancreatic β‐cell line and increases glucose output in rat hepatocytes[1].
Cotadutide (100 nM, 2 h) induces mitochondrial turnover and enhances mitochondrial function in mouse primary hepatocytes[2].

体内研究
(In Vivo)

Cotadutide (10 nmol/kg, s.c., once) suppresses food intake in DIO mice relative to vehicle‐ reated controls[1].
Cotadutide (10 or 30 nmol/kg, s.c., once daily for 14-16 weeks) reduces body weight in DIO mice[1].
Cotadutide (30 nmol/kg, s.c., once a day for 6 weeks) reduces hepatic fibrosis and inflammation in in ob/ob AMLN NASH mice[2].

Animal Model:Diet-induced obesity (DIO) mice[1]
Dosage:10 nmol/kg
Administration:Subcutaneousinjection (s.c.)
Result:Showed a redction of food intake in mice after an acute administration.
Animal Model:Diet-induced obesity (DIO) mice[1]
Dosage:10 or 30 nmol/kg
Administration:Subcutaneousinjection (s.c.)
Result:Reduced body weight and food intake, and improved glucose tolerance in DIO mice.
Clinical Trial
分子量

3728.09

Formula

C167H252N42O55

CAS 号

1686108-82-6

Sequence

1'-{palmtoyl-Glu}; His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Lys-Ser-Glu-Tyr-Leu-Asp-Ser-Glu-Arg-Ala-Arg-Asp-Phe-Val-Ala-Trp-Leu-Glu-Ala-Gly-Gly (Amide bridge: Glu1'-Lys10)

Sequence Shortening

1'-{palmtoyl-Glu}; HSQGTFTSDKSEYLDSERARDFVAWLEAGG (Amide bridge: Glu1'-Lys10)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.