P32/98 hemifumarateis a potent inhibitor ofdipeptidyl peptidaseIVwith a K_ivalue of 130 nM. P32/98 hemifumarate improves glucose tolerance,insulinsensitivity and β-cell responsiveness in fatty Zucker rat model^[1][2][3].

GLP-1 acts function of stimulation of glucose dependent insulin secretion and induction of satiety feelings, and DPPIV is the major renal catabolic pathway for GLP-1 in vivo^[2].
P32/98 hemifumarate, together with 200 pM GLP-1, (10 μM; 3 h) shows no significant inhibition of sodium re-absorption in porcine proximal tubular cells^[2].
P32/98 hemifumarate (10 μM; 96 h) does not influence the mRNA expression of GLP-1R, DPPIV, Na⁺/H⁺exchanger isoform 3 (NHE3), sodium-dependent glucose transporter slc5a1, slc5a2 (SGLT1, 2)^[2].

P32/98 hemifumarate (25 mg/kg; i.g.; once daily) long-time treatment significantly improves the glucose tolerance in Zucker diabetic fatty rats, a model of IGT (impaired glucose tolerance)^[3].

260.36

C₉H₁₈N₂OS.1/2C₄H₄O₄

251572-86-8

异亮氨酸噻唑烷半富马酸盐

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Please store the product under the recommended conditions in the Certificate of Analysis.