Pirmenol

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Pirmenol

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

68252-19-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

Cl-845 free base
(±)-Pirmenol

产品介绍

Pirmenol 是一种具有口服活性的抗心律失常剂。Pirmenol 通过阻断毒蕈碱性受体 (mAchR) 来抑制I_K.ACh(IC₅₀: 0.1 μM)。可用于心血管疾病的研究，如心房颤动。Pirmenol 通过阻断毒蕈碱性受体 (mAchR) 来抑制I_K.ACh(IC₅₀: 0.1 μM)。Pirmenol 可用于心血管疾病的研究，如心房颤动。

生物活性

Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibitsI_K.ACh(IC₅₀: 0.1 μM) by blockingmAchR. Pirmenol can be used in the research ofcardiovascular disease, such as atrial fibrillation^[1]^[2]^[4].

IC₅₀& Target

IC50: 0.1 μM (I_K.ACh)^[1]

体外研究
(In Vitro)

Pirmenol (1 μM) inhibits the I_K.AChinduced by carbachol or intracellular loading of GTPg S in in atrial cells^[1].
Pirmenol (5 μM) depresses the early part of the plateau and lengthened the final repolarization of the action potentials in ventricular myocytes^[3].
Pirmenol (1 μM) prolongs the action potential duration at 90% repolarization in atrial muscles and Purkinje fibers^[3].

体内研究
(In Vivo)

Pirmenol (2.5 and 5 mg/kg, p.o.) is effective against the arrhythmias in conscious, coronary artery ligated dogs^[4].
Pirmenol (rats) shows LD₅₀s of 359.9 mg/kg (p.o), 23.6 mg/kg (i.v.)^[2].
Pirmenol (mice) shows LD₅₀s of 215.5 mg/kg (p.o), 20.8 mg/kg (i.v.)^[2].

Animal Model:	Conscious, coronary artery ligated dogs^[4]
Dosage:	Oral administration (p.o.)
Administration:	2.5 and 5 mg/kg
Result:	Restored normal sinus rhythm, and showed a long duration of activity, wide safety margin.

分子量

338.49

Formula

C₂₂H₃₀N₂O

CAS 号

68252-19-7

中文名称

吡美诺；吡哌醇

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.