Dicyclomine

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Dicyclomine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

77-19-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

Dicycloverine

产品介绍

Dicyclomine (Dicycloverine) 是一种有效的口服活性毒蕈碱胆碱能受体 (muscarinic cholinergic receptors) 拮抗剂。Dicyclomine (Dicycloverine) 对 M1 受体亚型 (K_i=5.1 nM) 和 M2 受体亚型 (K_i=54.6 nM) 在刷缘膜和基底质膜中均表现出较高的亲和力。Dicyclomine (Dicycloverine)是一种抗痉挛试剂，在体内可缓解胃肠道平滑肌痉挛。

生物活性

Dicyclomine (Dicycloverine) is a potent and orally activemuscarinic cholinergic receptorsantagonist. Dicyclomine (Dicycloverine) shows high affinity for muscarinic M1 receptor subtype (K_i=5.1 nM) and M2 receptor subtype (K_i=54.6 nM) in brush-border membrane and basal plasma membranes, respectively^[1]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo^[2].

体内研究
(In Vivo)

Dicyclomine (Dicycloverine) (intraperitoneal injection; 8 mg/kg; daily) exacerbates the cognitive impairments in all the measurements. In addition, the memory impairments are worse in dicyclomine-treated 3xTg-AD mice compared to dicyclomine-treated NonTg mice^[2].
Dicyclomine (Dicycloverine) (intraperitoneal injection; 2.0, 4.0, and 8.0 mg/kg; 7 days) produces a highly significant effect on performance in the paired-associates learning (PAL) task in mice.And systemic treatment at lower doses show behavioral impairments in mice in spatial tasks^[3].

Animal Model:	C57Bl/6 mice^[1]
Dosage:	2.0, 4.0, and 8.0 mg/kg
Administration:	Intraperitoneal injection; daily; 7 days
Result:	Produced impairments due to actions of the agent outside of the hippocampus.

分子量

309.49

Formula

C₁₉H₃₅NO₂

CAS 号

77-19-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.