Cevimeline (AF-102B) is a quinuclidine derivative of acetylcholine and a selective and orally activemuscarinic M1 and M3 receptoragonist. Cevimeline stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia^[1][2][3][4]. Cevimeline can cross the blood-brain barrier (BBB)^[5].

Muscarinic M1 and M3 receptor^[1]

In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca²⁺concentration^[1].

Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg^[1].

199.31

C₁₀H₁₇NOS

107233-08-9

西维美林；西维米林

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.