CAS NO: | 1314140-00-5 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | TC-N 22A is a potent, selective, orally active and brain-permeablemGlu4PAM with anEC50of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo[1]. |
IC50& Target | EC50: 9 nM (mGlu4receptor)EC50: >10 μM (mGlu 1, 2, 3, 5, and 7 receptors)[1] |
体外研究 (In Vitro) | TC-N 22A is selected for mGlu4and has an EC50of 9 nM in human mGlu4-expressing BHK cells. This compound is less active in agonist and PAM modelinactive (EC50>10 μM), and is inactive in negative allosteric modulator (NAM) model at mGlu 1, 2, 3, 5, and 7 receptors (IC50>10 μM) and shows low potential for hERG channel inhibition[1]. |
体内研究 (In Vivo) | TC-N 22A (oral administration; 10 mg/kg) displays good plasma (259 ng/mL) and brain exposure levels (200 ng/mL) as well as good brain penetration (brain/plasma ratios of 0.8) after 1 h following a 10 mg/kg oral administration in SpragueDawley rats[1]. |
分子量 | 283.35 |
Formula | C14H13N5S |
CAS 号 | 1314140-00-5 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
溶解性数据 | In Vivo:
|