3,3'-Difluorobenzaldazine

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

15332-10-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

DFB

产品介绍

3,3'-Difluorobenzaldazine (DFB) 是一种选择性 mGluR5 正变构调节剂。3,3'-Difluorobenzaldazine 可增强 mGlu5 激动剂 (Glutamate, Quisqualate, 3,5-Dihydroxyphenylglycine) 的 3-6 倍作用，EC₅₀在 2 到 5 μM 范围内。

生物活性

3,3'-Difluorobenzaldazine (DFB) is a selective positive allosteric modulator ofmGluR5. 3,3'-Difluorobenzaldazine potentiates 3- to 6-fold action for mGlu5 agonists (Glutamate, Quisqualate, and 3,5-Dihydroxyphenylglycine), with EC₅₀s in the 2 to 5 μM range^[1].

体外研究
(In Vitro)

3,3'-Difluorobenzaldazine (DFB) causes a concentration-dependent potentiation of the response of human mGluR5 CHO cells to 300 nM glutamate in this assay. The maximal potentiation at this concentration of glutamate is approximately 3.1-fold, with an EC₅₀for potentiation of 2.6 μM. 3,3'-Difluorobenzaldazine causes similar potentiation of the responses of both human mGluR5 and rat mGluR5 CHO cells to glutamate, quisqualate, and DHPG with comparable potencies^[1].

体内研究
(In Vivo)

3,3'-Difluorobenzaldazine (40-100 nmol; icv) attenuates the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine^[2].

Animal Model:	Male NMRI and ICR mice (8-9 weeks, 33-40 g)^[2]
Dosage:	40-100 nmol (~9.7-24.4 μg)
Administration:	ICV
Result:	Attenuated the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine.

分子量

244.24

Formula

C₁₄H₁₀F₂N₂

CAS 号

15332-10-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.