| CAS NO: | 135306-85-3 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 生物活性 | Men 10376 is a selectivetachykinin NK-2 receptorantagonist, with aKiof 4.4 μM for rat small intestine NK-2 receptor. |
| IC50& Target | Ki: 4.4 μM (NK-2 receptor, rat small intestine)[1] |
| 体外研究 (In Vitro) | Men 10376 is a selective tachykinin NK-2 receptor, with a Kiof 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2]. |
| 体内研究 (In Vivo) | Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2]. |
| 分子量 | 1081.22 |
| Formula | C57H68N12O10 |
| CAS 号 | 135306-85-3 |
| Sequence | Asp-Tyr-{d-Trp}-Val-{d-Trp}-{d-Trp}-Lys-NH2 |
| Sequence Shortening | DY-{d-Trp}-V-{d-Trp}{d-Trp}-K-NH2 |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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