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[D-Pro2,D-Trp7,9] Substance P
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
[D-Pro2,D-Trp7,9] Substance P图片
CAS NO:80434-86-2
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
[D-Pro2,D-Trp7,9] Substance P，是 Substance P (HY-P0201) 的类似物，是一种弱激动剂，是一种有效的、特异性、竞争性的Substance P拮抗剂。
生物活性

[D-Pro2,D-Trp7,9] Substance P, aSubstance P(HY-P0201) analogue, is a weak agonist and a potent, specific, competitiveSubstance Pantagonist[1][2].

体外研究
(In Vitro)

[D-Pro2,D-Trp7,9] Substance P decreases proliferation only in a few cell lines, and only in the highest concentration (100 μM). [D-Pro2,D-Trp7,9] Substance P displays a significantly weaker antiproliferative action thanAprepitant(HY-10052) on cancer or normal cell lines[3].

体内研究
(In Vivo)

[D-Pro2,D-Trp7,9] Substance P (0-30 nmol, Intravitreal injection) greatly reduces not only the effects of exogenousSubstance P(HY-P0201) but also the inflammatory response to trauma to the eye[1].
[D-Pro2,D-Trp7,9] Substance P specifically antagonizes the contractile effects of Substance P on the guinea-pig isolated taenia coli[2].

Animal Model:Adult pigmented rabbits (1.5-3 kg)[1]
Dosage:0.03, 0.3, 3, and 30 nmol
Administration:Intravitreal injection or topical application onto the eye, 60 μL
Result:Reduced the inflammatory response to Substance P. Dependently reduced the inflammatory response to infrared irradiation. In itself, intravitreal injection of low doses of [D-Pro2, D-Trp7'9]SP had no effects on the eye.
分子量

1515.82

Formula

C74H106N20O13S

CAS 号

80434-86-2

Sequence Shortening

RPKPQQWFWLM-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

 ContentsAssign value
Acidic amino acidAsp (D), Glu (E), and the C-terminal -COOH.-1
Basic amino acidArg (R), Lys (K), His (H), and the N-terminal -NH2+1
Neutral amino acidGly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)0

3.  Recommended solution:

Overall charge of peptideDetails
Negative (<0)1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.