MAK683-CH2CH2COOH is a drug-linker conjugate used in the synthesis of PROTAC-based EED (embryonic ectoderm development protein) degraders. MAK683-CH2CH2COOH can be connected via a linker to a VHL ligand for the E3 ubiquitin ligase. MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI50 of 14 nM for 14 days treatment.
纯度：≥98%
CAS：2639882-68-9
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