Atracurium (BW-33A free acid) 是一种有效的、竞争性的和非去极化的神经肌肉阻滞剂 (neuromuscular blocking)。Atracurium 还是一种 AChR 受体拮抗剂。Atracurium 可诱导支气管收缩和神经肌肉阻滞。Atracurium 促进星形胶质细胞分化[5]。
| 生物活性 | tracurium (BW-33A free acid) is a potent, competitive and non-depolarizingneuromuscular blockingagent.Atracurium also is an AChR receptor antagonist. Atracurium induces bronchoconstriction and neuromuscular blockade. Atracurium promotes astroglial differentiation[1][2][3][4][5]. |
体外研究
(In Vitro) | Atracurium (10 μM; 72 h) promotes astroglial but not neuronal differentiation in HSR040622 and HSR040821 cells[4].
Atracurium (10 μM; 48 h) reduces tumor engraftment and increases survival of mice xenotransplanted with ex-vivo treated GSCs[4].
Atracurium (2.4 μM; 120 min) induces a complete fade of the tetanic contraction while only slightly affected the twitch in rat extensor digitorum longus muscle cells[5].
Cell Proliferation Assay[4] | Cell Line: | glioblastoma stem (GSC) cells | | Concentration: | 3, 10, 20 μM | | Incubation Time: | 72 h | | Result: | Increased the percentage of GFP-positive cells in a dose-dependent manner from 5.3% in DMSO to 15.4%, 81.1%, and 86.8% in 3 μM, 10 μM, and 20 μM, respectively. |
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体内研究
(In Vivo) | Atracurium (1, 5, 10, 20, 50 mg/kg; i.v.) induces bronchoconstriction in DBA/2 and SJL mice[2].
Atracurium (4.8 mg/kg; i.v.) induces neuromuscular blockade in rats[3].
| Animal Model: | 5-12 weeks, 15-20 g male mice[2] | | Dosage: | 1, 5, 10, 20, 50 mg/kg | | Administration: | I.v. | | Result: | Induced bronchoconstriction and Atracurium-induced airway hyperresponsiveness in DBA/2 mice was eliminated in a dose-dependent manner by pretreatment with atropine or pancuronium. |
| Animal Model: | 290 ± 30 g Male Sprague±Dawley rats (60 mg/kg heat-killedCorynebacteriumparvumfor i.v.)[3] | | Dosage: | 4.8 mg/kg | | Administration: | I.v. | | Result: | Induced neuromuscular blockade inCorynebacteriumparvum-injected rats. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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