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Oxiconazole
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Oxiconazole图片
CAS NO:64211-45-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
奥昔康唑
Ro 13-8996 free base
产品介绍
Oxiconazole (Ro 13-8996) 是一种广谱抗真菌剂,能抑制念珠菌 (Candida)、曲霉属真菌 (Aspergillus) 和毛癣菌属真菌 (Trichophyton) 的生长。Oxiconazole 也是一种高效的CYP3A4反式激活剂,可与利福平 (Rifampicin; HY-B0272) 竞争性拮抗。Oxiconazole 通过过氧化物酶 2 (PRDX2) 介导的细胞自噬 (autophagy) 停滞来发挥抗结直肠癌的作用。
生物活性

Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungalagent which can inhibit the growth ofCandida,AspergillusandTrichophyton. Oxiconazole is also a highly efficacious activator ofCYP3A4transactivation, which could be antagonized byRifampicin(HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectalcancer(CRC) via peroxiredoxin-2 (PRDX2)-mediatedautophagyarrest[1][2][3].

IC50& Target[2]

CYP3A4

 

体外研究
(In Vitro)

Oxiconazole (24 h; 0-40 μM) inhibits CRC cell growth[3].
Oxiconazole has antifungal activity againstCandida,AspergillusandTrichophyton[1].
Antifungal Activities of Oxiconazole[1].

Candida
albicans
Candida
glabrata
Candida
parapsilosis
Aspergillus
fumigatus
Aspergillus
flavus
Trichophyton
mentagrophytes
Trichophyton
rubrum
Oxiconazole0.03 μg/mL0.01 μg/mL0.008 μg/mL2 μg/mL2 μg/mL2 μg/mL2 μg/mL

Cell Proliferation Assay[3]

Cell Line:HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460
Concentration:0-40 μM
Incubation Time:24 h
Result:Exhibited inhibitory activity against HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460 with IC50s of 25.86 μM, 27.34 μM, 21.01 μM, 25.56 μM, 21.75 μM, 24.87 μM and 126.4 μM.
体内研究
(In Vivo)

Oxiconazole (50 mg/kg/day; IP; for 12 days) significantly restrains CRC cell growth[3].

Animal Model:BALB/c nude mice (injected subcutaneously with HCT116 cells (1×107/mouse)[3]
Dosage:50 mg/kg/day
Administration:IP; for 12 days
Result:Significantly restrained CRC cell growth and showed no obvious side effects.
Clinical Trial
分子量

429.13

Formula

C18H13Cl4N3O

CAS 号

64211-45-6

中文名称

奥昔康唑

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.