CAS NO: | 723-46-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
100mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
生物活性 | Sulfamethoxazole (Ro 4-2130) is a sulfonamide bacteriostaticantibiotic, used forbacterialinfections. Sulfonamides is a competitive antagonists of para-aminobenzoic acid (PABA)[1]. | ||||||||||||||||
IC50& Target | Antibacterial | ||||||||||||||||
体外研究 (In Vitro) | Sulfonamides are structural analogs and competitive antagonists of para-aminobenzoic acid (PABA). They inhibit normal bacterial utilization of PABA for the synthesis of folic acid, an important metabolite in DNA synthesis. The effects seen are usually bacteriostatic in nature. Folic acid is not synthesized in humans, but is instead a dietary requirement. This allows for the selective toxicity to bacterial cells (or any cell dependent on synthesizing folic acid) over human cells. Bacterial resistance to sulfamethoxazole is caused by mutations in the enzymes involved in folic acid synthesis that prevent the drug from binding to it. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 253.28 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C10H11N3O3S | ||||||||||||||||
CAS 号 | 723-46-6 | ||||||||||||||||
中文名称 | 磺胺甲恶唑;新诺明;磺胺甲基异恶唑 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 100 mg/mL(394.82 mM) H2O : 0.1 mg/mL(0.39 mM;Need ultrasonic) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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