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Aripiprazole
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aripiprazole图片
CAS NO:129722-12-9
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
1g电议
5g电议

产品介绍
Aripiprazole (OPC-14597) 是一种非典型抗精神病药,是一种有效且高亲和力的多巴胺 D2 受体部分激动剂。
Cas No.129722-12-9
别名阿立哌唑; OPC-14597
化学名7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
Canonical SMILESC1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
分子式C23H27Cl2N3O2
分子量448.39
溶解度≥ 22.4mg/mL in DMSO
储存条件Store at 2-8℃, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Aripiprazole is a novel and atypical antipsychotic [1].

Aripiprazole has been found to be a dopamine-serotonin system stabilizer with potent partial agonist activity at dopamine D2 and 5-HT1A receptors and antagonist activity at 5-HT2A receptors. In addition, aripiprazole has been reported to label with the agonist [125I]7-OH-PIPAT and with the antagonist [3H]spiperone with 0.34±0.02nM and 0.70±0.22nM, respectively. Besides, aripiprazole has been revealed to dose-dependently and potently inhibit the increase in cAMP accumulation stimulated by forskolin in CHO cells and HEK-293 cells. Other results have also been reported that aripiprazole completely inhibited the increase GTPase activity stimulated by the D2 receptor agonist quinpirole in rat striatal membranes [1].

References:
[1] Burris KD1, Molski TF, Xu C, Ryan E, Tottori K, Kikuchi T, Yocca FD, Molinoff PB. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. J Pharmacol Exp Ther. 2002 Jul; 302(1):381-9.