| CAS NO: | 320345-99-1 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 320345-99-1 |
| 别名 | 阿地溴铵; LAS 34273; LAS-W 330 |
| 化学名 | [(3R)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octan-3-yl] 2-hydroxy-2,2-dithiophen-2-ylacetate;bromide |
| Canonical SMILES | C1C[N+]2(CCC1C(C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O)CCCOC5=CC=CC=C5.[Br-] |
| 分子式 | C26H30BrNO4S2 |
| 分子量 | 564.55 |
| 溶解度 | ≥ 28.2275mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Aclidinium Bromide is a long-acting antagonist of muscarinic (LAMAs) [1]. Aclidinium Bromide has been reported to inhibit the specific binding of [3H]-NMS to human M receptors in a dose-denpendent fasion with Ki values of 0.10±0.00nM,0.14±0.04nM, 0.14±0.02nM, 0.21±0.04nM and 0.16±0.01nM for M1, M2,M3,M4 and M5, respectively. In addition, Aclidinium Bromide has shown the great potency at endogenous M2 and M3 receptors with EC50 values of 17.4±1.1nM and 5.3±1.6nM, respectively. Apart from these, Aclidinium Bromide has been revealed to produce a concentration-dependent inhibition of acetylcholine-induced bronchoconstriction in vivo with an EC50 of ranging from 2.5 to 23.1μg/mL in anaesthetized guines pigs. Besides, Aclidinium Bromide has also been noted to inhibit the salivation in rat pilocarpine-induced sialorrhea model with an EC50 of 38μg/kg [1]. References: |
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