5'-Methoxynobiletin 是一种口服有效的镇痛和抗炎剂。5'-Methoxynobiletin 是一种聚甲氧基黄酮类化合物，可以从蒿属植物中分离出来。
| 生物活性 | 5'-Methoxynobiletin is a potent and orally activeantinociceptiveandanti-inflammatoryagent. 5'-Methoxynobiletin is a polymethoxyflavone, that can be isolated from A. conyzoides[1][2]. |
体内研究
(In Vivo) | 5'-Methoxynobiletin (5mg /kg, 腹腔注射) 可显著降低白细胞计数、中性粒细胞流入和渗出液中的蛋白质浓度，并降低几种促炎介质的水平[2]。< br/>5'-Methoxynobiletin (100 mg/kg，口服，一次) 显示出抗伤害和抗炎活性[2]。
5'-Methoxynobiletin (10 mg/kg，静脉注射；50 mg/kg，口服；一次) 在大鼠体内的口服生物利用度较低，约为 8-11%[2]。
| Animal Model: | Swiss mice (female)[2] | | Dosage: | 100 mg/kg | | Administration: | Orally | | Result: | Significantly reduced both phases of formalin-induced nocifensive behavior after 15, 30 and 60 min of oral administration, when compared to control groups. In the neurogenic phase, inhibitions of 43±3%, 68±6% and 53±5% of the nociceptive response were observed, while for the infammatory phase inhibitions were 70±8%, 91±3% and 85±3% after 15, 30 and 60 min of the oral administration of 5'-Methoxynobiletin, respectively. |
| Animal Model: | Wistar rats (male)[2] | | Dosage: | 10 mg/kg (IV), 50 mg/kg (oral) | | Administration: | IV, oral, once (Pharmacokinetic Analysis) | | Result: | Pharmacokinetic Parameters of 5'-Methoxynobiletin in male Wistar rats[1].
| IV (10 mg/kg) | IG (50 mg/kg) | | λ (h-1) | 0.55±0.03 | 0.29±0.2 | | Tmax(h) | | 2.71±0.49 | | Cmax(mg/L) | | 0.62±0.21 | | AUC0-∞(mg·h/L) | 8.19±4.1 | 3.65±0.8 | | t1/2elimination (h) | 1.26±0.1 | 2.31±0.9 | | CL (L/h.kg) | 1.22±0.26 | 13.68±0.29 | | Vd, ss (L/kg) | 2.24±0.32 | 47.46±10.10 | | F (%) | | 8.67 |
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| 来源 | - Plants
- Leguminosae
- Lupinus perennisL.
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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