Bakkenolide B

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Bakkenolide B

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

18455-98-6

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议

产品介绍

Bakkenolide B 是从petasites japonicas叶片中分离出来的，具有抗过敏和抗炎作用。 Bakkenolide B 可用于研究哮喘。

生物活性

Bakkenolide B is isolated frompetasites japonicasleaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma^[1].

体外研究
(In Vitro)

Bakkenolide B (0-100 μg/ml; pretreatment 30 mins) inhibits antigen-induced β-hexosamidase release from RBL2H3 mast cells in a concentration-dependent manner^[1].
Bakkenolide B (0-10 μg/ml; 1 h later stimulated with LPS) strongly inhibits the gene inductions of inducible nitric oxide synthase and cyclooxygenase-2 in a concentration-dependent manner in mouse peritoneal macrophages^[1].

Western Blot Analysis^[1]

Cell Line:	Mouse peritoneal macrophages
Concentration:	0 μg/ml; 1 μg/ml; 3 μg/ml; 5 μg/ml; 10 μg/ml
Incubation Time:	1 h later stimulated with LPS
Result:	Decreased iNOS and cox-2 protein expression.

体内研究
(In Vivo)

Bakkenolide B (intraperitoneal injection; 1 mg/ml; 1 h before ovalbumin nebulization on days 28, 29, and 30) strongly inhibits the accumulation of eosinophils, macrophages, and lymphocytes to bronchoalveolar lavage fluid (BALF) in ovalbumin-induced asthma mice^[1].

Animal Model:	Ovalbumin-induced asthma mice^[1]
Dosage:	1 mg/ml
Administration:	Intraperitoneal injection; 1 h before ovalbumin nebulization on days 28, 29, and 30
Result:	Exhibited anti-allergic effects in mice.

分子量

390.47

Formula

C₂₂H₃₀O₆

CAS 号

18455-98-6

结构分类

Terpenoids
Other Terpenoids

来源

Plants
Leguminosae
PiptadeniaBenth.

Plants
Compositae

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.