| CAS NO: | 300-08-3 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
| Cas No. | 300-08-3 |
| 别名 | 氢溴酸槟榔碱 |
| 化学名 | methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate;hydrobromide |
| Canonical SMILES | CN1CCC=C(C1)C(=O)OC.Br |
| 分子式 | C8H14BrNO2 |
| 分子量 | 236.11 |
| 溶解度 | ≥ 11.8mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Arecoline hydrobromide is a nicotinic acids-based alkaloid and partial agonist of muscarinic acetylchiline M1, M2, M3 and M4 receptors. The LD50 of subcutaneous injection value is 100 mg/kg in mouse [1]. Arecoline hydrobromide has been suggested to have electrophysiological effects on ventricular myocytes. Arecoline hydrobromide has shown the significant inhibitory effect on hERG current with the IC50 value of 9.55μmol/L. Furthermore, Arecoline hydrobromide has demonstrated the concentration- , time- and voltage-dependent characteristics of IhERG inhibition in the patch clamp experiments. Apart from these, Arecoline hydrobromide has been exhibited to significant change in the amount of steady-state blockade at stimulation frequencies. It has been shown frequency-dependent characteristics inhibition of IhERG by Arecoline hydrobromide [1]. References: |
m.cnreagent.com