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Cyproheptadine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cyproheptadine hydrochloride图片
CAS NO:969-33-5
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
Cyproheptadine hydrochloride 是一种有效且具有口服活性的 5-HT2A 受体拮抗剂,具有抗抑郁和抗血清素作用。
Cas No.969-33-5
别名盐酸赛庚啶
化学名4-(dibenzo[1,2-a:1',2'-e][7]annulen-11-ylidene)-1-methylpiperidine;hydrochloride
Canonical SMILESCN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1.Cl
分子式C21H22ClN
分子量323.86
溶解度≥ 14.15mg/mL in DMSO
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cyproheptadine hydrochloride is an antagonist of serotonin receptor [1].

Cyproheptadine is a serotonin and histamine antagonist as well as an antimuscarinic reagent. It is used to treat for postgastrectomy-dumping syndrome, pruritic dermatoses, migraine, anorexia, and pituitary-dependent Cushing's syndrome. The major urinary product of cyproheptadine is cyproheptadine glucuronide, a quaternary ammonium compound. Cyproheptadine has some side effects including sedation, drowsiness, hypotension, tachycardia and blood dyscrasias. As a 5-HT2A receptor antagonist, cyproheptadine is found to reverse serotonin-enhanced ADP-induced platelet aggregation in vitro and ex vivo suggesting its antiplatelet and thromboprotective effects. [1, 2]

References:
[1] Levine B, Green-Johnson D, Hogan S, Smialek JE.  A cyproheptadine fatality. J Anal Toxicol. 1998 Jan-Feb;22(1):72-4.
[2] Lin OA, Karim ZA, Vemana HP, Espinosa EV, Khasawneh FT.  The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. PLoS One. 2014 Jan 23;9(1):e87026.