| Cas No. | 29769-49-1 |
| 化学名 | N-(6-formyl-3,4-dihydro-4-oxo-2-pteridinyl)-acetamide |
| Canonical SMILES | CC(NC(N1)=NC(N=CC(C=O)=N2)=C2C1=O)=O |
| 分子式 | C9H7N5O3 |
| 分子量 | 233.2 |
| 溶解度 | DMF: 50 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 0.1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Acetyl-6-formylpterin is an inhibitor of mucosal-associated invariant T (MAIT) cell activation. It dose-dependently increases the surface expression of MHC-related 1 (Mr1) in WT3 cells overexpressing Mr1 (WT3-m) following incubation with E. coli but does not activate MAIT cells cocultured with WT3-m cells when used at concentrations ranging from 0.23-15 uM. Acetyl-6-formylpterin is also a degradation product of folic acid and a precursor in the synthesis of 2'-hydroxy-7,8-dihydrofolate, which is a metabolite of para-aminosalicylic acid (PAS) in M. tuberculosis. |
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