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α-Guanidinoglutaric Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
α-Guanidinoglutaric Acid图片
CAS NO:73477-53-9
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
linear mixed-type inhibitor of nNOS
Cas No.73477-53-9
别名(S)-(-)-2-胍基戊二酸,GGA
化学名N-(aminoiminomethyl)-L-glutamic acid
Canonical SMILESNC(=N)N[C@@H](CCC(=O)O)C(=O)O
分子式C6H11N3O4
分子量189.2
溶解度≤50mg/ml in aqueous solutions
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

α-Guanidinoglutaric Acid is a novel nitric oxide synthase inhibitor with Ki value of 2.69 μM [1].

In the brain, nitric oxide (NO), which is synthesized from L-arginine (Arg) by NO synthase (NOS), acts as both an intra- and an intercellular second messenger, and it may suppress convulsions [1].

α-Guanidinoglutaric Acid (GGA) is a novel nitric oxide synthase inhibitor. GGA was increased in the cobalt-induced epileptic focus tissue in the cerebral cortex of cats [2]. GGA is an endogenous, potent, and non-guanidino nitrogen-substituted NOS inhibitor and that inhibition of nitric oxide biosynthesis may be involved in GGA-induced convulsions. In the cobalt-induced epileptic focus, GGA might inhibit NO production. GGA is a useful tool for the study of the enzyme-substrate relationship of NOS [1].

In rats, GGA injected in the cerebroventricle caused sporadic spike discharges with a latency of several minutes. When Arg was supplemented with GGA, no sporadic spike discharges were observed. These results indicated that Arg elevated the threshold of GGA-induced seizures. The initiation of the seizures induced by GGA was associated with a decrease in the 5-hydroxytryptamine level [1].

References:
[1].  Yokoi I, Kabuto H, Habu H, Mori A. alpha-Guanidinoglutaric acid, an endogenous convulsant, as a novel nitric oxide synthase inhibitor. J Neurochem. 1994 Oct;63(4):1565-7.
[2].  Mori A, Akagi M, Katayama Y, et al. alpha-Guanidinoglutaric acid in cobalt-induced epileptogenic cerebral cortex of cats. J Neurochem. 1980 Sep;35(3):603-5.