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L-NMMA(citrate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
L-NMMA(citrate)图片
包装与价格：
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
别名L-NG-monomethyl Arginine citrate
化学名N5-[imino(methylamino)methyl]-L-ornithine, citrate
Canonical SMILESCN([H])/C(N([H])CCC[C@@H](C(O)=O)N)=N/[H].OC(CC(O)=O)(C(O)=O)CC(O)=O
分子式3[C7H16N4O2] · C6H8O7
分子量756.8
溶解度≤6mg/ml in PBS
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

L-NMMA (citrate) is a relatively non-selective inhibitor of all NOS isoforms [1].

Nitric oxide synthases (NOSs) belong to a family of enzymes involved in catalyzing the production of nitric oxide (NO) from L-arginine. As an important cellular signaling molecule, NO has been implicated in modulating vascular tone, insulin secretion, airway tone, and peristalsis, angiogenesis and neural development. Until now, three isozymes of NOS have been identified: eNOS (endothelial NOS), nNOS (neuronal NOS), and iNOS (inducible NOS). The eNOS plays a critical role in embryonic heart development and morphogenesis of coronary arteries and cardiac valves. The nNOS functions as a retrograde neurotransmitter important in long term potentiation and has been involved in the development of nervous system. The iNOS produces large amounts of NO as a defense mechanism and is an important factor in the response of the body to attack by parasites, bacterial infection, and tumor growth [2].

L-NMMA inhibited the activity of NOS with the Ki values of approximately 0.18, 0.4, and 6 μM for nNOS (rat), eNOS (human), and iNOS (mouse), respectively [1]. In perfused dog mesenteric artery segments, treatment with L-NMMA increased the vasoconstriction induced by adrenergic nerve stimulation. In dog cerebral artery strips, L-NMMA suppressed the relaxant response to transmural nerve stimulation [3]. In patients with cardiogenic shock, L-NMMA administration is safe and has favorable clinical and hemodynamic effects [4].

References:
[1] Frey C, Narayanan K, McMillan K, et al.  L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases[J]. Journal of Biological Chemistry, 1994, 269(42): 26083-26091.
[2] Stuehr D J, Griffith O W.  Mammalian nitric oxide synthases[J]. Advances in Enzymology and Related Areas of Molecular Biology, Volume 65, 2006: 287-346.
[3] TODA N, OKAMURA T.  Modification by L-NG-monomethyl arginine (L-NMMA) of the response to nerve stimulation in isolated dog mesenteric and cerebral arteries[J]. The Japanese Journal of Pharmacology, 1990, 52(1): 170-173.
[4] Cotter G, Kaluski E, Blatt A, et al.  L-NMMA (a nitric oxide synthase inhibitor) is effective in the treatment of cardiogenic shock[J]. Circulation, 2000, 101(12): 1358-1361.