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β-acetyl-Boswellic Acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
β-acetyl-Boswellic Acid图片
CAS NO:5968-70-7
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
β-acetyl-Boswellic Acid 是一种从齿叶乳香树胶树脂中分离出来的乳香酸。
Cas No.5968-70-7
别名3-乙酰基-BETA-乳香酸,ABA,3-O-acetyl-β-Boswellic acid,β-Boswellic acid acetate
化学名(3α,4β)-3-(acetyloxy)-urs-12-en-23-oic acid
Canonical SMILESC[C@]1(C(O)=O)[C@H](OC(C)=O)CC[C@]2(C)[C@@]3([H])CC=C4[C@](CC[C@]5(C)[C@@]4([H])[C@@H](C)[C@H](C)CC5)(C)[C@]3(C)CC[C@]21[H]
分子式C32H50O4
分子量498.7
溶解度≤5mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

β-acetyl-Boswellic Acid is a specific, nonreducing-type inhibitor of the 5-LO product formation with selectivity over 12-LO and COX [1][2].

5-lipoxygenase (5-LO) is a member of the lipoxygenase family of enzymes and transforms EFA substrates into leukotrienes.

In rat peritoneal neutrophils, boswellic acids concentration dependently decreased the formation of leukotriene B4 from endogenous arachidonic acid. In isolated human platelets, boswellic acids in concentrations up to 400 μM did not impair the cyclooxygenase and 12-lipoxygenase [1]. In calcium/calcium ionophore-stimulated peritoneal neutrophils of rats, boswellic acids significantly decreased production of LTB4 and total 5-lipoxygenase products with EC50 value of about 30 μg/ml [2]. In six human myeloid leukemia cell lines, boswellic acid acetate, a 1:1 mixture of α-boswellic acid acetate and β-boswellic acid acetate induces apoptosis through caspase-mediated pathways [4].

Boswellic acids are pentacyclic triterpenes with putative anti-inflammatory effects. In a mouse model of osteoarthritis (OA), boswellic acid significantly attenuated articular cartilage erosion and significantly reduced knee synovitis and osteophyte formation. In synovium of mice, boswellic acid directly inhibit IL-1β and TLR4 induced inflammatory cytokines production [3].

References:
[1].  Safayhi H, Mack T, Sabieraj J, et al. Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. J Pharmacol Exp Ther. 1992 Jun;261(3):1143-6.
[2].  Ammon HP, Safayhi H, Mack T, et al. Mechanism of antiinflammatory actions of curcumine and boswellic acids. J Ethnopharmacol. 1993 Mar;38(2-3):113-9.
[3].  Wang Q, Pan X, Wong HH, et al. Oral and topical boswellic acid attenuates mouse osteoarthritis. Osteoarthritis Cartilage. 2014 Jan;22(1):128-32.
[4].  Xia L, Chen D, Han R, et al. Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells. Mol Cancer Ther. 2005 Mar;4(3):381-8.