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N-Benzylacetamidine(hydrobromide)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-Benzylacetamidine(hydrobromide)图片
CAS NO:186545-76-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
iNOS inhibitor
Cas No.186545-76-6
化学名N-(phenylmethyl)-ethanimidamide, monohydrobromide
Canonical SMILESCC(NCC1=CC=CC=C1)=N.Br
分子式C9H12N2· HBr
分子量229.1
溶解度≤25mg/ml in ethanol;15mg/ml in DMSO;20mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 0.20 μM: inhibits inducible nitric oxide synthases (iNOS).

IC50: 350 μM: blocks endothelial nitric oxide synthases (eNOS).

N-Benzylacetamidine is a potent and selective inhibitor of iNOS compared to eNOS. NOS is essential to the formation of nitric oxide (NO) via the NADPH- and O2-dependent oxidation of L-arginine, which plays a role in regulating many pathological and physiological processes, including smooth muscle relaxation and neurotransmission. INOS contributes to immune response and inflammation while eNOS plays a vital role in regulating vascular tone.

In vitro: N-Benzylacetamidine showed good iNOS and almost negligible eNOS inhibition in THP-1 cells, a human myelomonocytic leukemia cell line [1].

In vivo: Up to now, in vivo study of N-Benzylacetamidine is still in the development stage.

Reference:
[1].  Maccallini, C., Patruno, A., Besker, N., Ali, J., Ammazzalorso, A., & De Filippis, B. et al. Synthesis, Biological Evaluation, and Docking Studies of N-Substituted Acetamidines as Selective Inhibitors of Inducible Nitric Oxide Synthase. Journal of Medicinal Chemistry. 2009; 52(5): 1481-1485.