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Benzoquinonium dibromide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Benzoquinonium dibromide图片
CAS NO:311-09-1
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Benzoquinonium dibromide 是一种烟碱型乙酰胆碱受体 (nAChRs) 拮抗剂,IC50 为 0.46 μM。
Cas No.311-09-1
化学名3,3'-((3,6-dioxocyclohexa-1,4-diene-1,4-diyl)bis(azanediyl))bis(N-benzyl-N,N-diethylpropan-1-aminium) bromide
Canonical SMILESO=C1C(NCCC[N+](CC)(CC)CC2=CC=CC=C2)=CC(C(NCCC[N+](CC)(CC)CC3=CC=CC=C3)=C1)=O.[Br-].[Br-]
分子式C34H50Br2N4O2
分子量706.6
溶解度<70.66mg/ml in DMSO
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Benzoquinonium Dibromide (BZQ) is an inhibitor of acetylcholine receptor (AChR) and ganglion. BZQ activates nicotinic single channels but blocks open channels at the neuronal AChRs.
AChR is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter. Nicotinic acetylcholine receptor (nAChR) are particularly responsive to nicotine and is a Na+ and K+ channel.
The effects of BZQ on α-BGT sensitive neuronal nAChRs were evaluated on outside-out patches excised from fetal rat hippocampal neurons cultured for 11 to 35 days and found that BZQ (0.1-10 μM) could activate single-channel currents. BZQ was also able to activate various channel conductance states. The two most frequently encountered conductance states activated by BZQ were 43 ± 3.3 pS and 30 ± 4.2 p5. In frog muscle fibers, BZQ is an open-channel blocker of the nAChR and also activates single-channel currents that are not blocked by a-BGT.
References:
[1]. Pereira EF, Reinhardt-Maelicke S, Schrattenholz A, et al. Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons. J Pharmacol Exp Ther, 1993, 265(3): 1474-1491.