Capillarisin 作为蒿属植物蒿的一种成分，具有抗炎和抗氧化作用。Capillarisin 可为哮喘介导并发症的研究，并且可以作为一种潜在的神经保护剂来对抗布比卡因引起的神经毒性。
| 生物活性 | Capillarisin, as a constituent from Artemisiae Capillaris herba, is found to exert anti-inflammatory and antioxidant properties. Capillarisin can be used for the research of asthma-mediated complications and can be a potential neuroprotectant against bupivacaine-induced neurotoxicity[1][2][3]. |
体外研究
(In Vitro) | Capillarisin (0~40 μM; 24 hours; SH-SY5Y cells) does not produce any significant changes on the viability of SH-SY5Y cells[3].
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Capillarisin (40 μM; 24 hours; SH-SY5Y cells) induces PI3K/PKB pathway inactivation, which inhibiting apoptosis in bupivacaine-challenged SH-SY5Y cells is overturned by LY294002 treatment and counteracts bupivacaine-induced injury via activating the PI3K/PKB pathway[3].
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Capillarisin antagonizes bupivacaine-induced oxidative stress via activating the PI3K/PKB pathway in SH-SY5Y cells. Capillarisin inhibits bupivacaine-induced mitochondrial injury and endoplasmic reticulum stress via activating PI3K/PKB pathway[3].
Cell Viability Assay[3] | Cell Line: | SH-SY5Y cells | | Concentration: | 0~40 μM | | Incubation Time: | 24 hours | | Result: | Did not produce any significant changes on the viability of SH-SY5Y cells. |
Western Blot Analysis[3] | Cell Line: | SH-SY5Y cells | | Concentration: | 40 μM | | Incubation Time: | 24 hours | | Result: | Induced PI3K/PKB pathway inactivation in SH-SY5Y cells. |
Apoptosis Analysis[3] | Cell Line: | SH-SY5Y cells | | Concentration: | 40 μM | | Incubation Time: | 24 hours | | Result: | Induced inhibition of apoptosis in bupivacaine-challenged SH-SY5Y cells was overturned by LY294002 treatment. |
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体内研究
(In Vivo) | Capillarisin (20 and 80 mg/kg; i.p.; 1 hour) pretreatment strongly inhibits NF-κB mediated genes (iNOS, COX-2)[4].
Capillarisin significantly reduces the plasma leading nitrite production. Capillarisin markedly suppresses the adenosine 5'-triphosphate (ATP) in plasma and substance P in CFA-induced paw tissue[4].
| Animal Model: | ICR mice[4] | | Dosage: | 20 and 80 mg/kg | | Administration: | I.p.; 1 hour | | Result: | Pretreatment strongly inhibited NF-κB mediated genes (iNOS, COX-2). |
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| 来源 | - Plants
- Compositae
- Artemisia capillarisThunb.
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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