CAS NO: | 477-43-0 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots ofSaussurea costus. IC50 value: Target: In vitro: Dehydrocostus Lactone promotedapoptosiswith increased activation of caspases 8, 9, 7, 3, enhancedPARPcleavage, decreasedBcl-xLexpression and increased levels ofBax,Bak, Bok, Bik, Bmf, and t-Bid. We have demonstrated that Dehydrocostus Lactone inhibits cell growth and induceapoptosisin DU145 cells [1]. Dehydrocostus Lactone inhibits NF-kappaB activation by preventing TNF-alpha-induced degradation and phosphorylation of its inhibitory protein I-kappaB alpha in human leukemia HL-60 cells and that dehydrocostus lactone renders HL-60 cells susceptible to TNF-alpha-inducedapoptosisby enhancingcaspase-8and caspase-3 activities [2]. Dehydrocostus Lactone inhibited the production of NO in lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric oxide synthase enzyme expression. In vivo: Dehydrocostus Lactone decreased theTNF-alphalevel in LPS-activated systems in vivo [3]. | ||||||||||||||||
分子量 | 230.30 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C15H18O2 | ||||||||||||||||
CAS 号 | 477-43-0 | ||||||||||||||||
中文名称 | 去氢木香烃内酯 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 250 mg/mL(1085.54 mM;Need ultrasonic) Ethanol : 15 mg/mL(65.13 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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