Vitamin U (S-Methylmethionine sulfonium) chloride是一种具有抗氧化活性的口服抗溃疡剂。Vitamin U chloride 抑制脂肪细胞分化。Vitamin U chloride 可促进皮肤伤口愈合。Vitamin U chloride 可用于胃肠道溃疡的研究。
| 生物活性 | Vitamin U (S-Methylmethionine sulfonium) chloride is an orally active anti-ulcer agent with antioxidant activity. Vitamin U inhibits adipocyte differentiation. Vitamin U promotes skin wound healing.Vitamin U can be used in the research of gastrointestinal ulceration[1][2][3][4][5]. |
体外研究
(In Vitro) | Vitamin U chloride (100 μM, 24 h) promotes the growth and migration of human dermal fibroblasts(hDFs)[1].
Vitamin U chloride (0-1 mM, 24 h) activates ERK1/2 in hDFs[1].
Vitamin U chloride (0.1 g/L in the nutrient solution) reduces cell membrane damage in higher plants exposed to low-temperature stress[2].
Vitamin U chloride (10-100 mM, 7 days) inhibits adipocyte differentiation via down-regulation of adipogenic factors and up-regulation of AMPK activity[3].
Cell Proliferation Assay[1] | Cell Line: | Human dermal fibroblasts(hDFs) | | Concentration: | 100 μM | | Incubation Time: | 24 h | | Result: | Promoted hDFs proliferation. |
Western Blot Analysis[3] | Cell Line: | 3T3-L1 cells | | Concentration: | 50, 70, 90 mM | | Incubation Time: | 7 days | | Result: | Increased AMPK phosphorylation and decreased PPAR-γ levels. |
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体内研究
(In Vivo) | Vitamin U chloride (50 mg/kg, oral gavage) prevents valproic acid-induced liver injury in rats[4].
Vitamin U chloride (50 mg/kg, oral gavage for 3 days) shows antioxidant effect and prevents GalN-induced gastric damage in rats[5].
| Animal Model: | Valproic acid (VPA)-induced rats with liver damage[4] | | Dosage: | 50 mg/kg | | Administration: | Oral gavage | | Result: | Blocked the decrease in catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities.
Increased in the levels of IL-1β, active caspase-3, and cytoplasmic cytochrome c.
Increased in the number of proliferating cells nuclear antigen (PCNA) positive hepatocytes. |
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| 来源 | - Plants
- Compositae
- Wollastonia biflora(Linnaeus) Candolle
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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