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Visnagin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Visnagin图片
CAS NO:82-57-5
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议

产品名称
齿阿米素
产品介绍
Visnagin 是一种抗氧化剂呋喃香豆素衍生物,具有抗炎特性,可用于缓解疼痛的研究。Visnagin 具有预防Cerulein 诱导的急性胰腺炎 (AP) 的潜力。Visnagin 在血管平滑肌中具有良好的血管扩张作用。
生物活性

Visnagin, an antioxidant furanocoumarin derivative, possess anti-inflammatory and analgesic properties. Visnagin has substantial potential to prevent Cerulein induced acute pancreatitis (AP). Visnagin possess promising vasodilator effects in vascular smooth muscles[1][2].

体外研究
(In Vitro)

Visnagin (10 μM; for 4, 8, 16, 24 h) induces CYP1A1 transcription in HepG2 cells[1].
Visnagin (10 μM; for 16 h) elevates CYP1B1 gene expression in an aryl hydrocarbon receptor (AHR)-dependent manner, whereas MNF (3’-methoxy-4’-nitroflavone; 20 μM; pre-treated for 1 h) successfully counteracted this induction. Visnagin also enhances PAI-2 transcription in an AHR-dependent manner[1].

体内研究
(In Vivo)

Visnagin (10, 30, 60 mg/kg; ip; for 7 days) is effective in reducing plasma amylase and lipase levels and reduces Cerulein (50 μg/kg, six, hourly i.p. injections) induced oxidative stress in male Swiss albino mice (age: 6-8 weeks, weighing 20-25 g)[1].
Visnagin dose dependently decreases the expression of IL-1β, IL-6, TNF-α and IL-17. It attenuates the levels of nuclear p65-NFκB. Visnagin improves the antioxidant defence by improving Nrf2 expression and halts pancreatic inflammation by suppressing NFκB and nitrotyrosine expression in the acinar cells[1].

分子量

230.22

性状

Solid

Formula

C13H10O4

CAS 号

82-57-5

中文名称

齿阿米素;阿密茴素;甲氧呋豆素

结构分类
  • Ketones, Aldehydes, Acids
来源
  • Plants
  • Umbelliferae
  • Ammi visnaga(L.) Lam
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO :< 1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble or slightly soluble)

Ethanol :< 1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble)

DMF :< 1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble)