您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > N6-Benzyladenosine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
N6-Benzyladenosine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N6-Benzyladenosine图片
CAS NO:4294-16-0
包装与价格:
包装价格(元)
100mg电议
200mg电议
500mg电议

产品名称
Benzyladenosine
产品介绍
N6-Benzyladenosine 是一种腺苷受体激动剂,具有细胞分裂素 (cytokinin) 活性。N6-Benzyladenosine 能将细胞周期阻滞在 G0/G1,并诱导凋亡 (apoptosis)。N6-Benzyladenosine 显示出对弓形虫腺苷激酶和胶质瘤 (glioma) 的抑制作用。
生物活性

N6-Benzyladenosine is anadenosine receptoragonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cellapoptosis. N6-Benzyladenosine also exerts inhibitory effect onT. gondiiadenosine kinaseand glioma[1]-[5].

体外研究
(In Vitro)

N6-benzyladenosine suppresses the clonogenic activity and the growth of different neoplastic cells[2].
N6-benzyladenosine results cell morphology alteration and actin cytoskeleton disorganization in T24 cell[2].
N6-benzyladenosine (10 μM; 24 h) is a potent inductor of apoptosis, and belongs to apoptotic systems with distinct caspase-3 and caspase-9 activation[3].
N6-benzyladenosine (0-100 μM; 24 h) induces chromatin condensation, formation of apoptotic bodies, and cleavage of DNA to nucleosomal fragments in a dose-dependent manner[3].
N6-benzyladenosine acts as a selective anti-toxoplasma agent with binding affinity toT. gondiiadenosine kinase (apparent Km=179.8 μM), over human adenosine kinase[4].
N6-benzyladenosine (0-50 μM) shows weak inhibition against adenosine kinase deficient (TgAKS3) strains of Toxoplasma gondii[4].
N6-benzyladenosine (compound 2) (0.3-20 μM) exerts anti-glioma activity by interfering with the mevalonate pathway and inhibiting FPPS (Farnesyl pyrophosphate synthase)[5].

Apoptosis Analysis[3]

Cell Line:HL-60
Concentration:10 μM
Incubation Time:24 hours
Result:Induced cell apoptosis by increasing caspase-3 (DEVDase) as well as caspase-9 (LEHDase) activity, indicating an apoptotic systems with distinct caspase-3/9 activation.

Apoptosis Analysis[5]

Cell Line:U87MG human glioma cell line.
Concentration:0.3, 0.6, 1.2, 2.5, 5, 10, 20 μM
Incubation Time:48 hours
Result:Inhibited glioma growth by interfering with the mevalonate pathway and inhibiting FPPS.
分子量

357.36

性状

Solid

Formula

C17H19N5O4

CAS 号

4294-16-0

结构分类
  • Others
来源
  • Plants
  • Umbelliferae
  • Pimpinella anisumL.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 125 mg/mL(349.79 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.7983 mL13.9915 mL27.9830 mL
5 mM0.5597 mL2.7983 mL5.5966 mL
10 mM0.2798 mL1.3991 mL2.7983 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。