Mahanimbine 是Murraya koenigii中的一种具有口服活性的生物碱。Mahanimbine 抑制高脂饮食 (HFD) 诱导的小鼠代谢并发症的进展。
| 生物活性 | Mahanimbine is an orally active alkaloid fromMurraya koenigii. Mahanimbine inhibits progression of high-fat diet (HFD)-induced metabolic complications in mice[1]. |
体内研究
(In Vivo) | Mahanimbine (2-4 mg/kg; p.o.; daily for 12 weeks) prevents HFD-induced weight gain in mice (male and female)[1].
Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress[1].
Mahanimbine treatment improves glucose clearance and upregulates the expression of insulin responsive genes in liver and adipose tissue[1].
| Animal Model: | Swiss albino mice (7-8 weeks old, both sex)[1] | | Dosage: | HFD+LD (2 mg/kg of body weight of mahanimbine), HFD+HD (4 mg/kg of body weight of mahanimbine); | | Administration: | Oral suspension; daily for 12 weeks | | Result: | Male HFD+LD and HFD+HD groups showed 51.70±6 3.59% and 47.37±3.73% weight gain, respectively, as compared with 71.02±6 6.04% in HFD fed mice whereas female HFD+LD and HFD+HD groups showed 24.31±1.68% and 25.10±2.61% weight gain as compared with HFD group with 36.69±3.60% of weight gain. |
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| 分子量 | |
| Formula | |
| CAS 号 | |
| 结构分类 | - Alkaloids
- Indole Alkaloids
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| 来源 | - Plants
- Rutaceae
- Murraya koenigii(L.) Spreng
- Plants
- Rutaceae
- Murraya exotica L. Mant.
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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