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Alstonine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alstonine图片
CAS NO:642-18-2
包装:5mg
市场价:12000元

产品介绍
Alstonine 是一种植物性药物的主要吲哚生物碱化合物。Alstonine 具有抗精神病,抗焦虑,抗癌和抗疟疾的特性。
生物活性

Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties[1].

体外研究
(In Vitro)

Alstonine has the capacity to distinguish cancer DNA from healthy tissue DNA; it inhibits DNA in vitro synthesis when DNA from different cancerous tissues or cells is used as template. Practically without effects on DNA from healthy tissues[1].

体内研究
(In Vivo)

In mice models Alstonine shows a clear, dose-dependent, potent antipsychotic profile. Alstonine (i.p.) prevents amphetamine-induced lethality, with active doses within the range of 0.5-2.0 mg/kg[1].
Alstonine (0.1, 0.5 and 1.0 mg/kg) prevents MK-801 induced hyperlocomotion. Because Alstonine partially reverses MK-801-induced increase in locomotion both at the hole-board and locomotor activity cages[1].
Alstonine successfully treats a relatively important proportion of BALB/C mice inoculated with transplantable YC8 lymphoma ascites cells as well as Swiss mice bearing Ehrlich ascites carcinoma cells[1].

分子量

348.40

性状

Solid

Formula

C21H20N2O3

CAS 号

642-18-2

结构分类
  • Alkaloids
  • Pyridine Alkaloids
  • Alkaloids
  • Indole Alkaloids
来源
  • Plants
  • Apocynaceae
  • Alstonia scholaris(L.) R. Br.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)