CAS NO: | 1781934-50-6 |
包装: | 50mg, 100mg, 250mg |
规格: | ≥98% |
AR-C102222 HCl is a highly potent, competitive, orally bioavailable and highly specific inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM. AR-C102222 HCl has antinociception and anti-inflammatory activities. References: [1]. Tinker AC, et al. 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. J Med Chem. 2003 Mar 13;46(6):913-6.
[2]. LaBuda CJ, et al. Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and post-operative pain. Eur J Pain. 2006 Aug;10(6):505-12. Epub 2005 Aug 24.
[3]. Yoon J, et al. Syntheses of 1,2,3-triazolyl salicylamides with inhibitory activity on lipopolysaccharide-induced nitric oxide production. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1953-7.
纯度:≥98%
CAS:1781934-50-6