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AR-C102222 HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1781934-50-6
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

AR-C102222 HCl is a highly potent, competitive, orally bioavailable and highly specific inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM. AR-C102222 HCl has antinociception and anti-inflammatory activities. References: [1]. Tinker AC, et al. 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. J Med Chem. 2003 Mar 13;46(6):913-6. [2]. LaBuda CJ, et al. Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and post-operative pain. Eur J Pain. 2006 Aug;10(6):505-12. Epub 2005 Aug 24. [3]. Yoon J, et al. Syntheses of 1,2,3-triazolyl salicylamides with inhibitory activity on lipopolysaccharide-induced nitric oxide production. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1953-7.

纯度:≥98%

CAS:1781934-50-6