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WIN 66,306
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
WIN 66,306图片
CAS NO:151928-32-4
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
A peptide antagonist of NK1and NK2receptors
Cas No.151928-32-4
Canonical SMILESO=C(N1[C@@](C(NCC(N[C@H](C(NCC(N[C@@](C(NCC(N2)=O)=O)([H])[C@@H](C3=CC(C/C=C(C)\C)=C(C=C3)O)O)=O)=O)C(C)C)=O)=O)([H])CCC1)[C@@H]2CC4=CNC5=CC=CC=C45
分子式C41H52N8O9
分子量800.9
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

WIN 66,306 is a cyclic heptapeptide antagonist of neurokinin-1 (NK1) and NK2receptors originally isolated fromA. flavipes.1It binds to NK1and NK2receptors (Kis = 8 and 3.8 µM, respectively, for the human receptors) and inhibits contractions induced by substance P in isolated guinea pig ileum in a concentration-dependent manner.

1.Barrow, C.J., Doleman, M.S., Bobko, M.A., et al.Structure determination, pharmacological evaluation, and structure-activity studies of a new cyclic peptide substance P antagonist containing the new amino acid 3-prenyl-β-hydroxytyrosine, isolated from Aspergillus flavipesJ. Med. Chem.37(3)356-363(1994)