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Pritelivir mesylate hydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pritelivir mesylate hydrate图片
CAS NO:1428321-10-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议

产品名称
AIC316 mesylate hydrate
BAY 57-1293 mesylate hydrate
产品介绍
Pritelivir mesylate hydrate (BAY 57-1293 mesylate hydrate) 是一种病毒解旋酶-引物酶复合物 (helicase-primase complex) 抑制剂,在体外和单纯疱疹病毒 (HSV) 感染的动物模型中均具有抗病毒活性。Pritelivir mesylate hydrate 对 1 型和 2 型单纯疱疹病毒 (HSV-1HSV-2) 具有活性,对 HSV1-2 的 IC50为 0.02 μM。
生物活性

Pritelivir mesylate hydrate (BAY 57-1293 mesylate hydrate), an inhibitor of the viralhelicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV)infection. Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (HSV-1andHSV-2) with the IC50of 0.02 μM against HSV1-2[1].

IC50& Target[1]

HSV-1

0.02 μM (IC50)

HSV-2

0.02 μM (IC50)

体内研究
(In Vivo)

Pritelivir is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase–primase enzyme complex[2].
Pritelivir (0.03-45 mg/kg) significantly increases survival. Pritelivir (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Pritelivir has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis[3].
Combination therapies of Pritelivir at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS[3].

Animal Model:Female BALB/c mice[3]
Dosage:0.03 to 45 mg/kg
Administration:Administered orally, twice daily at approximately 12 h intervals, for 7 days
Result:Survival was significantly increased to 80-100% as compared to the vehicle treatment. Even the lowest dose of 0.3 mg/kg was effective in increasing survival to 53%.
Clinical Trial
分子量

516.61

性状

Solid

Formula

C19H24N4O7S3

CAS 号

1428321-10-1

中文名称

普瑞利韦甲磺酸盐一水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)