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Penciclovir Sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Penciclovir Sodium图片
CAS NO:97845-62-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
VSA 671 sodium
BRL 39123A
BRL 39123D
产品介绍
Penciclovir (VSA 671) sodium 是一种有效的选择性抗疱疹病毒 (anti-herpesvirus) 剂,对于 HSV-1(HFEM),HSV-2(MS) 的EC50值分别为 0.5, 0.8 μg/ml。Penciclovir sodium 显示抗疱疹病毒活性且无细胞毒性。Penciclovir sodium 可防止小鼠死亡。
生物活性

Penciclovir (VSA 671) sodium is a potent and selectiveanti-herpesvirusagent withEC50values of 0.5, 0.8 μg/ml forHSV-1(HFEM),HSV-2(MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse[1][2].

IC50& Target[1]

HSV-1

0.5 μg/mL (EC50)

HSV-2

0.8 μg/mL (EC50)

体外研究
(In Vitro)

Penciclovir sodium (0-100 μg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 μg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively[1].
Penciclovir sodium (0-100 μg/ml) shows no-toxic to uninfected human cells[1].

Cell Cytotoxicity Assay[1]

Cell Line:MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells
Concentration:0-100 μg/ml
Incubation Time:
Result:Showed no-toxic with IC50s of >100, >100, 100, >100, 60, >100, >100, >100, >100, >100, >100, >100 for MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells, respectively.
体内研究
(In Vivo)

Penciclovir sodium (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse[2].

Animal Model:Three-week-old female Balb/c mice[2]
Dosage:100 mg/kg
Administration:S.c.; daily for 5 days
Result:Reduced virus titres in the respiratory organs of both w/t- and PR3-infected mice.
Clinical Trial
分子量

275.24

Formula

C10H14N5NaO3

CAS 号

97845-62-0

中文名称

喷昔洛韦钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.