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JZP-361
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JZP-361图片
CAS NO:1680193-80-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
JZP-361是一种有效的、可逆的、选择性的人重组MAGL(hMAGL) 抑制剂,IC50为 46 nM。JZP-361 还具有抗组胺能活性,可用于哮喘的研究。
生物活性

JZP-361 is a potent, reversible and selective inhibitor of human recombinantMAGL(hMAGL) with anIC50of 46 nM. JZP-361 also shows antihistaminergic activities and can be used for asthma research[1].

IC50& Target

hMAGL

46 nM (IC50)

hABHD6

1.79 μM (IC50)

hFAAH

7.24 μM (IC50)

H1Receptor

6.81 (pA2)

体外研究
(In Vitro)

JZP-361 has almost 150-fold higher selectivity over human recombinant fatty acid amide hydrolase (hFAAH, IC50= 7.24 μM) and 35-fold higher selectivity over human α/β-hydrolase-6 (hABHD6, IC50= 1.79 μM)[1].
JZP-361 retains H1antagonistic affinity (pA2 = 6.81) but did not show cannabinoid receptor activity, when tested at concentrations ≤10 μM[1].
JZP-361 displays favorable interactions within the active site of hMAGL including the important hydrogen-bonding of the carbonyl oxygen to the oxyanion hole[1].

分子量

405.88

Formula

C22H20ClN5O

CAS 号

1680193-80-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.