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Colistin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1066-17-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
抗敌素
Polymyxin E
产品介绍
Colistin (Polymyxin E) 是一种多肽抗生素,具有口服活性。Colistin 对多种革兰氏阴性杆状细菌(包括多重耐药的铜绿假单胞菌、鲍曼不动杆菌和肺炎克雷伯菌)等均有良好的抑制活性。Colistin 与肾毒性有关,可用于革兰氏阴性菌感染的研究。
生物活性

Colistin (Polymyxin E) is an orally activepolypeptideantibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistantPseudomonas aeruginosa,Acinetobacter baumanniiandKlebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli[1][2].

体内研究
(In Vivo)

Colistin (Polymyxin E) (16 mg/kg/day, i.p.) shows the enrichment of cell cycle arrest genes and suggests that injury or cellular stress caused by colistin is acting through p53 to inhibit cell cycle progression[1].
Colistin (16 mg/kg/day, i.p.) has elevated blood urea nitrogen (BUN), creatinine, and pathologic evidence of acute tubular necrosis and apoptosis[1].

Animal Model:C57/BL6 mice[1]
Dosage:16 mg/kg/day
Administration:16 mg/kg/day, i.p.
Result:Detected apoptosis, necrosis PCNA staining in mice.
Clinical Trial
分子量

1169.50

Formula

C53H100N16O13(for E1)

CAS 号

1066-17-7

中文名称

抗敌素,多黏菌素E

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.